Ointment containing spray freeze-dried metronidazole effective against rosacea

Rosacea is a chronic, inflammatory skin disease that affects about 10% of the population. Metronidazole-containing ointments are typically recommended for daily treatment symptoms. For increasing bioavailability and effectiveness, it needed to reduce particle size. Therefore, micronized metronidazole was prepared by spray freeze-drying (SFD) method, then its most important features were examined such as morphology, crystallinity The anti-inflammatory effect as-prepared agent tested on mouse model rosacea effectiveness against oedema redness ears, compared reference cream. Metronidazole size reduced successfully SFD 2.7 μm from 162.6 μm. material non-porous preserved crystalline state. freeze-dried mixed into ointment effective ear-redness. in five times lower doses (2 × 0.04 mg metronidazole) ear-redness half dose 0.2 than cream containing 2 0.4 metronidazole, respectively). In conclusion, technique an adequate gentle procedure reducing which highly rosacea.